RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
CDKN1A
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
homo sapiens
Detection Methods
BrdU incorporation assay; qRT-PCR; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation
Year
2012
Function
"Compared with controls, in high-altitude long-term hypoxia(LTH)fetus pulmonary arteries,global histone 4 acetylation and DNA methylation levels are reduced, accompanied by the loss of the cyclin-dependent kinase inhibitor p21. Treatment of LTH fetal PASMCs with histone deacetylase (HDAC) inhibitor trichostatin A decreased their proliferation rate, PDGF-induced cell migration, ERK1/2 activation and modulated global DNA methylation. Epigenetic alterations (reduced histone acetylation and DNA methylation) caused by chronic hypoxia leads to fetal PASMC proliferation and vessel remodeling associated with vascular proliferative disease and that this process is regulated by p21."
RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
CDKN1A
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
homo sapiens
Detection Methods
BrdU incorporation assay; qRT-PCR; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation
Year
2012
Function
"Compared with controls, in high-altitude long-term hypoxia(LTH)fetus pulmonary arteries,global histone 4 acetylation and DNA methylation levels are reduced, accompanied by the loss of the cyclin-dependent kinase inhibitor p21. Treatment of LTH fetal PASMCs with histone deacetylase (HDAC) inhibitor trichostatin A decreased their proliferation rate, PDGF-induced cell migration, ERK1/2 activation and modulated global DNA methylation. Epigenetic alterations (reduced histone acetylation and DNA methylation) caused by chronic hypoxia leads to fetal PASMC proliferation and vessel remodeling associated with vascular proliferative disease and that this process is regulated by p21."